The Handlery in Union Sq. would fit your requirements and is a nice boutique hotel. It is very close to the cable car lines, major shopping, China Town and not far from the Wharf via cable car or taxi.I need a good recommendation also. Mom has stage 4 breast cancer & this trip is at the TOP of her bucket list. (We're whale watching in Monterey also.) We need to stay somewhere safe, with NO outdoor entry rooms. I'm terrible at directions, so I won't be renting a car. We'll want to do the cable cars & some tours. I don't want to hijack OPs thread, but didn't want to start a new one with same info. Thanks so much, Angela