I just got back from DL and we went to Universal on a Sat. I want to say that I just took the 5 all the way there. There were exit signs very clearly marked. It took about 45 minutes. I left the hotel at 7am and arrived at Universal at 7:45. We had 1 hr 15 min to find something to do. I was very amazed at how easy it was to get to places there. Of course with weekday traffic, it may take longer.
Also, if you have not already bought your tickets, I highly recommend the Front Of The Line Pass ($20.00 cheaper over the internet) We got on everything at least once and did our favorites many times over. As bad as this sounds, I actually liked the FOTL pass better that Disneys fastpasses. We waited no more than 5 minutes to get on anything and that was only because the previous ride had to end.