I-65 to Nashville, I-24 to Chattanooga, I-75 to around Wildwood FL., Florida Sunshine Turnpike to US 27, US 27 to FL 192, to Disney.
Take I-465 around west side of Indianapolis ( it may say I-465 south?)
Take I-285 around Atlanta (especially during rush hour. I did it once and it made Chicago rush hour look like the Indy 500.)
Take I-475 around Macon, Ga.
Drive time about 20 hours