We always say we will drive further the first day to Georgia but never seem to leave quite early enough. South Carolina always winds up being our stopping point which is about 9 hours.We drive down from Baltimore. I've done both the one shot drive overnight (highly don't recommend) and stopping overnight. We like to stop in Georgia, which puts us at about 9ish hours of driving for the day, and around 4 hours from Disney. I'd pick a good mid point for yourself and find a nice hotel/food area to stop at that's not too far from I-95. Maybe somewhere in SC?