Just like Canada, the Interstates in the Northern US are great in the winter... unless they're not. I think we have always hit some snow on I-81 through upper NYS, even with blue skies. The lake effect just does that - but they have plenty of snow clearing equipment in the areas that get snow. In general I think the Northern states do a better job of keeping up the roads than we Canadians do. Most of the horror stories come from the Mid to Southern states that don't normally get snow/ice and can't cope.
The trick to planning the winter drive is to allow some slack in your schedule and watch the weather starting a few days before. Summer drivers plan their departures for an exact time so they can avoid traffic, or make hotel reservations en route, etc. Winter drivers should plan their departure based on weather conditions. Driving from Eastern Ontario, we have options of when we cut over to I-95 from I-81 so we can sometimes leave the Appalachians between us and a storm. Southern Ontario has route options too if you watch the weather. We figure out about when we want to leave, but always have Plan B/C that has us leaving 8 hours sooner or later. 16 hours flex is generally enough to avoid most weather unless it is barrelling straight up the coast.
If the weather is looking really atrocious, be prepared to trim a day off your vacation either end. This hasn't happened to us yet, but we've been lucky. The hardest part is staying in touch with Northern weather while you are in sunny FL - I have plenty of friends who have left at their scheduled date/time only to run into some terrible storms on the way home that could have been avoided if they had been paying attention.