Given that you're still working and want access to a major airport and big city amenities, Tampa is definitely your best bet of the three. The job and business markets are healthy and you have access to pretty much everything. And anything you can't find here, if you absolutely need it, you can get in either Orlando or Sarasota/Bradenton.
Housing is definitely pricey--you'll be looking at a minimum of 300k for any single family house you'd actually want to live in, and just keep adding if you want space, updates, amenities, or a central location. Townhomes and condos will be cheaper, but they're also smaller and will come with fees, some of which can be eye-watering.
There's nothing wrong with the Palm Coast or Space Coast areas at all, they're just sleepier and won't have all of the infrastructure or amenities it sounds like you're looking for. Maybe keep them in mind for a place to retire, though!
Good luck with whatever you choose!