I prefer POR but also really enjoy POFQ.
Here are some things to consider:
POR has a larger main pool area, the slide is longer it has waterfall type things and I think its a better pool area for adults or kids over say age 7 or 8 (but perfectly great for young kids as well). POR also has quiet pools right there, POFQ only has the one pool right there, its a much smaller resort. You can use any of the pools at POR as a POFQ guest. But for many, walking over to POR to swiim is not that convenient.
Not all buildings at POR have elevators. The entire Alligator Bayou section of POR is two story buildings without elevators. So if you have concerns with this, request a first floor room or go with FQ to be safe.
POR has a full serve restaurant, POFQ does not (again, its a short walk or bus ride, or boat ride to POR).
POR has bike rentals, boat rentals, fishing (catch and release) and surrey bike rentals.
POFQ is the first to be picked up and dropped off when it shares busses with POR (which has been almost always for our three stays there). So you will pretty much always get a seat on the bus as a FQ guest. Not always the case with POR.
Here is a great website about both resorts with lots of information and photos:
http://www.portorleans.org/